Search results for "Immune-escape mutation"

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Impact of HBV genotypes A and D genetic variability on infection evolution

2015

HBV is characterized by a high genetic variability, which is the basis of its classification into eight genotypes (A-H). HBV infection is associated with different outcomes, from self-limiting acute hepatitis to active chronic hepatitis, asymptomatic carriage, and occult infection. The aim of this study was to analyze the genetic variability of HBV genotypes A and D isolates from 79 cases of self-limiting acute hepatitis and chronic hepatitis, in order to identify HBV variants associated with resolution or chronicity of acute HBV infection. The entire preS-S sequence and a fragment of 346 bp of the preC-C region, containing Enhancer II and Basal Core Promoter sequences, were analyzed. A phy…

AdultMaleMicrobiology (medical)Hepatitis B virusSettore MED/07 - Microbiologia E Microbiologia ClinicaGenotypeAcute hepatitis BBiologymedicine.disease_causeMicrobiologyLiver diseaseViral ProteinspreC/C mutationGeneticImmune-escape mutationGenetic variationGenotypeGeneticsmedicineHumansViral ProteinGenetic variabilityMolecular BiologyEcology Evolution Behavior and SystematicsPhylogenyAgedHepatitis B virusPolymorphism GeneticpreS/S mutationGenetic VariationHepatitis B viruHepatitis BMiddle Agedmedicine.diseaseHepatitis BVirologyBiological EvolutionEcology Evolution Behavior and SystematicInfectious DiseasesAmino Acid SubstitutionViral evolutionImmunologyMutationFemaleViral hepatitisHuman
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